作为医药合成中间体，用于药物研发与制备。
医药
合成路线 1（1. 合成：28697-07-6）
产率：96.1%
合成条件：With sodium hydroxide In water at 20℃; for 12 h;
实验步骤：将10g 2-哌啶羧酸加入250ml四颈烧瓶，80g 10％氢氧化钠水溶液中，搅拌并溶解，并在完成后逐滴加入15.7g氢氧化钠和25g Cbz水溶液。 在室温下反应12小时。 取100克乙醚，用稀盐酸萃取水层至弱酸，然后萃取三次，合并有机层，用硫酸镁干燥，过滤，浓缩有机层，得到19.6克干产物（单步产率96.1％）。
参考文献：
- [1] Patent: US6337423, 2002, B1. Location in patent: Example 10 [2] Patent: CN105418489, 2016, A. Location in patent: Paragraph 0010; 0015 [3] Journal of Organic Chemistry, 1993, vol. 58, # 4, p. 860 - 866 [4] Journal of Chemical Research, 2008, # 8, p. 468 - 472 [5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 106 [6] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 5, p. 531 - 536 [7] Chemistry Letters, 2006, vol. 35, # 12, p. 1424 - 1425 [8] Journal of the Chinese Chemical Society, 1998, vol. 45, # 2, p. 293 - 296 [9] Tetrahedron, 1985, vol. 41, # 23, p. 5465 - 5474 [10] Tetrahedron Letters, 2002, vol. 43, # 48, p. 8759 - 8763 [11] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2225 - 2239 [12] Journal of Medicinal Chemistry, 2007, vol. 50, # 20, p. 4953 - 4975 [13] Patent: US5847155, 1998, A [14] Patent: US5106982, 1992, A [15] European Journal of Organic Chemistry, 2016, vol. 2016, # 21, p. 3631 - 3641
