381233-96-1 2-氨基-3-碘-5-溴吡啶

危险性质：非危险化学品

化学合成。

医药

合成路线 1（1. 合成：381233-96-1）

产率：90% 合成条件：Stage #1: at 100℃; Stage #2: With potassium iodide In water for 1.50 h; 实验步骤：制备9-苯磺酰基-3-溴-5-羟基-9H-二吡啶并[2,3-b]; 4'- 3，-dlpyrrole-6-腈步骤1：5-溴-3-碘 - 吡啶-2-基胺搅拌溶液 用碘酸钾（30.8g，144mmol）分批处理在2M硫酸（500mL）中的5-溴 - 吡啶-2-基胺（50g，289mmol），并将混合物加热至100℃。 在约1小时内滴加碘化钾（26.5g，160mmol）的水（50mL）溶液。 1小时。 将混合物再搅拌30分钟，然后冷却至环境温度。 将水相的pH调节至8-9并将混合物用乙酸乙酯（x3）萃取。 将合并的有机层用硫代硫酸钠水溶液，水和盐水洗涤，干燥（Na 2 SO 4）并蒸发，得到标题化合物，为棕色固体（77.4g，90％）。 NMR（300MHz，CDCl 3）：8.06（d，J = 2.2Hz，1H），7.96（d，J = 2.2Hz，1H），4.96（s，2H）。 参考文献：

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