63149-33-7 8-羟基-1,2,3,5,6,7-六氢吡啶并[3,2,1-ij]喹啉-9-甲醛

危险性质：否

化学合成。

化学合成

路线1：以8-羟基尿嘧啶7为原料合成

• 步骤：在含10mL DMF的烧瓶中，4℃下滴加氯氧化磷（2.7mL，4.4g，29mmol）15分钟；10分钟内滴加8-羟基尿嘧啶7（5.15g，26.9mmol）的DMF（5mL）溶液；室温搅拌30分钟后，100℃加热30分钟；冷却至室温后加入30mL水，搅拌1.5小时，过滤分离蓝绿色沉淀，水洗干燥；粗产物经硅胶柱色谱纯化（甲苯/EtOAc，2：1）。
• 条件：Stage #1: 4℃，0.25h；Stage #2: 4-100℃，2.50h。
• 产率：94%
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