55121-99-8 4-[(4-甲基-1-哌嗪基)羰基]苯胺

运输方式为冰袋运输。危险性质：非危险化学品。海关编码:2933599590

化学合成。

化学合成

路线1：4-氨基-苯基-(4-甲基-1-哌嗪-1-基)-甲酮合成

• 原料：(4-甲基-哌嗪-1-基)-(4-硝基-苯基)-甲酮（55121-99-8）
• 步骤：将Pd-C（150mg）加入到(4-甲基-哌嗪-1-基)-(4-硝基-苯基)-甲酮（440mg，1.7670mmol）的MeOH溶液中，在氢气氛下搅拌2小时。
• 监测：通过TLC（10％MeOH：CHCl₃）监测反应。
• 后处理：反应完成后，将混合物通过硅藻土床过滤，滤液浓缩。
• 收率：98%（得到380mg产物）
• 参考文献：[1] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 121；[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 9, p. 1615 - 1620；[3] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 80；[4] Patent: WO2004/26829, 2004, A2. Location in patent: Page/Page column 96；[5] Chemistry - An Asian Journal, 2017, vol. 12, # 7, p. 785 - 791；[6] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981, vol. 20, # 8, p. 680 - 682；[7] Patent: US2008/214558, 2008, A1. Location in patent: Page/Page column 23-24；[8] Patent: WO2004/63195, 2004, A1. Location in patent: Page 60-61；[9] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 9, p. 2740 - 2744；[10] Patent: WO2010/80474, 2010, A1. Location in patent: Page/Page column 134；[11] Patent: WO2010/71885, 2010, A1. Location in patent: Page/Page column 461；[12] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2917 - 2929；[13] Patent: US2012/277220, 2012, A1. Location in patent: Page/Page column 15-16；[14] Patent: US2018/223077, 2018, A1. Location in paragraph 0116; 0118