123524-52-7 阿折地平

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名称和标识

中文名: 阿折地平
英文名: Azelnidipine
CAS号: 123524-52-7
分子式: C33H34N4O6
分子量: 582.65
中文别名: 阿折地坪; 3-(1-二苯甲基氮杂环丁烷-3-基) 5-异丙基 2-氨基-6-甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯
英文别名: AZELNIDIPINE; 3-[1-(Diphenylmethyl)-3-azetidinyl]-5-(1-methylethyl-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; AZELINIDIPINE; CS-905; RS-9054; Azelidipine; Azenildipine; 3,5-Pyridinedicarboxylic acid (2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl); 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-[1-(Diphenylmethyl)azetidin-3-yl] 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-[1-(diphenylmethyl)azetidin-3-yl] 5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (±)-1,4-Dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-(1-Methylethyl) Ester; 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester; 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-Isopropyl (±)-2-Amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

安全说明

运输信息：常温运输。危险描述：非危险化学品，WGK Germany:3，RTECS号:US7968332，海关编码:2933.79.1500，毒性：雌性、雄性小鼠口服LD50分别为785、979mg/kg，雌性、雄性大鼠口服LD50分别为1267、1971mg/kg。

用途与制备

化学合成；生命科学；医药，抗高血压药物；属于二氢吡啶类钙通道阻滞剂（CCB），作为一线高血压治疗药，广泛用于轻症或中等症状原发性高血压、伴有肾功能障碍高血压及重症高血压患者，还用于心绞痛和充血性心衰治疗，具有利尿、心保护、肾保护及抗动脉硬化作用。

医药

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