2-碘-4-溴苯甲醚为醚类衍生物，属于多卤代苯化合物。多卤代苯化合物及其衍生物在有机合成、化工开发、微生物化学、医药、印染业及农业等多领域具有广泛应用并在近年越来越成为研究和开发的热点。
有机合成; 化工开发; 微生物化学; 医药; 印染业; 农业
路线1：
- 步骤: 向搅拌的底物（1mmol）的CH₂Cl₂或（CH₂Cl）₂（0.1M）溶液中加入Ph₃PAuNTf₂（0.025mmol，19mg；络合物Ph₃PAuNTf₂甲苯，2：1），然后加入N-碘代琥珀酰亚胺（1.1mmol，248mg）。将所得溶液在室温下搅拌或回流直至原料完全转化。
- 条件: 20℃；14h；溶剂为二氯甲烷和甲苯混合溶剂；催化剂为bis(trifluoromethanesulfonyl)imidategold(I)（Ph₃PAuNTf₂）；碘源为N-碘代琥珀酰亚胺（NIS）。
- 收率: 96%
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