化学合成。
化学合成
合成路线 1（1. 合成：443956-08-9）
产率：96%
合成条件：With bromine; sodium methylate In methanol at 0 - 20℃; for 1 h;
实验步骤：将3-羟基-2-硝基吡啶（20g，0.143mol）溶解在甲醇（400mL）中，在室温下加入25％甲醇钠的甲醇溶液（33mL，0.13mol）。 将混合物搅拌30分钟，然后冷却至0℃，缓慢加入溴（7.2mL，0.14mol）。 将反应在0℃搅拌30分钟，然后用冰AcOH（2.5mL）淬灭。 真空除去溶剂，得到物质（30g，96％），其无需进一步纯化即可使用：MS（ES）m / z219.0（M + H）+。
参考文献：
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