4-苄氧基-3-甲氧基苯乙酮是制备肾上腺素代谢物的中间体。
医药
合成路线 1（1. 合成：1835-11-6）
产率：99%
合成条件：With potassium carbonate In N,N-dimethyl-formamide at 40℃;
实验步骤：将4-羟基-3-甲氧基苯乙酮（40g，240mmol），苄基溴（31.4ML，260mmol）和碳酸钾（99.6g，360mmol）的DMF（800mL）溶液加热至40℃过夜。。 将溶液冷却至室温，倒在冰上，过滤得到的固体。 将该物质用水洗涤并干燥，得到1-（4-苄氧基-3-甲氧基苯基）乙酮（61g，99％）。
参考文献：
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合成路线 2（2. 合成：1835-11-6）
产率：94%
合成条件：With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 6 h;
实验步骤：将化合物18（8.3g，50mmol）溶于DMF（50mL）中，然后加入无水K 2 CO 3（2.5g）和苄基氯（6.3g，50mmol）。 将反应混合物在80℃下搅拌6小时。 将得到的粗产物溶解在H 2 O中，用EtOAc萃取，然后通过硅胶柱色谱法纯化，得到19（12g，94％），为白色粉末，m.p.205℃。 82-84°C; IR（纯）νmax2873,1670,1585,1512,1458,115,1350,1276,1215,1145,1076,991,871,798,748cm-1; 1HNMR（300MHz，CDCl3）δ7.57-7.33（7H，m），6.90（1H，d，J = 9.0Hz），5.23（2H，s），3.95（3H，s），2.55（3H，s）; 13CNMR（75MHz，CDCl3）δ296.6,152.2,149.3,136.1,130.5,128.5,127.9,127.0,122.9,111.9,110.3,70.6,55.8,26.0; EIMS m / z（rel.int。）：256 [M] +（39），92（26），91（100），65（24）; HREIMS计算值C 16 H 16 O 3 [M] + 256.1099，实测值256.1096。
参考文献：
- [1] European Journal of Medicinal Chemistry, 2012, vol. 48, p. 371 - 378
