4541-15-5 5-苄氧基-1-戊醇

危险性质：非危险化学品

未明确提及具体用途，主要作为中间体或原料用于医药相关合成（基于参考文献推测）。

医药

合成路线 1（1. 合成：4541-15-5）

产率：89% 合成条件：Stage #1: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1 h; Stage #2: at 20℃; for 2 h; 实验步骤：向搅拌的60％NaH在矿物油（2.30g，57.69mmol）中的分散体的悬浮液中缓慢加入1,5-戊二醇9（5.0g，48.07mmol）在无水DMF（150mL）中的溶液，历时15分钟。最低温度为0°C。然后将反应混合物在室温下搅拌1小时，然后在15分钟内加入苄基溴（5.75mL，48.07mmol）并在相同温度下再搅拌2小时。用冰冷的水淬灭反应混合物。将粗混合物用乙酸乙酯（2×30mL）萃取，将有机层用盐水洗涤（3次），用无水Na 2 SO 4干燥，并在真空下浓缩。残留物经硅胶柱层析纯化，用石油醚 - 乙酸乙酯（7：3）作洗脱液，得到苄基醚10.产量：89％（7.87g），无色油状物; IR（CHCl3，cm-1）：υmax700,714,1028,1072,1116,1177,1278,1316,1388,1453,2865,2938,3064,3332; 1H NMR（200MHz，CDCl3）：δ1.47-1.70（m，6H），3.47（t，J = 6.3Hz，2H），3.62（t，J = 6.1Hz，2H），4.49（s，2H）， 7.31（s，5H）; 13C NMR（50MHz，CDCl3）：δ22.3,29.3,32.3,62.2,70.2,72.8,127.5,128.2,138.3; HRMS（ESI）：计算值。 [（C 12 H 18 O 2）H]（M + H）195.1385，实测值195.1390。 参考文献：

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