50-04-4 醋酸可的松

名称和标识

中文名: 醋酸可的松
英文名: Cortisone acetate
CAS号: 50-04-4
分子式: C23H30O6
分子量: 402.48
中文别名: 醋酸肾上腺皮质激素; 可的松乙酸酯; 乙酸可的松; 乙酸肾上腺皮质激素; 21-乙酰氧基-17α-羟基孕甾-4-烯-3,11,20-三酮; 醋酸皮质酮; 可的松醋酸酯; 孕甾-4-烯-17α,21-二醇-3,11,20-三酮-21-醋酸酯
英文别名: 11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate; 11-dehydro-17-hydroxycorticosterone-21-acetate; 11-dehydro-17-hydroxycorticosteroneacetate; 17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate; 4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE; 4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE; 4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE; 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE; 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate; Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-; [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione; 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate; Cortisone 21-acetate; 2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate; Cortisone, 21-acetate; 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate; Cortisone (acetate)

安全说明

运输信息：常温运输。危险描述：非危险化学品；WGK Germany:3；RTECS号:GM9140000；海关编码:32041200；存储类别:11 - 可燃固体；危险性类别:生殖毒性类别2

用途与制备

生命科学，是氢化可的松的氧化代谢产物，具有免疫抑制和消炎的作用；肾上腺皮质激素类药物，具有抗炎、抗过敏等作用，用于治疗肾上腺皮质低功能症、类风湿性关节炎、风湿病、红斑狼疮等病；生化研究，作为泼尼松醋酸酯的中间体，本身为抗炎剂。

医药

路线1：

步骤: 用妊娠双烯醇酮经环氧化、沃氏氧化、霉菌氧化、铬酸氧化、溴化氢开环，雷尼镍催化脱溴、碘化并乙酰氧基置换制得。 路线2：
步骤: 以醋酸孕甾双烯醇酮为原料，依次经过氧化氢氧化、沃氏氧化、黑根菌生物氧化、铬酐氧化得11-酮基-16，17α环氧黄体酮，经氢溴酸开环，氢化脱溴得可的松，后者与碘反应，再与熔融醋酸钾作用得粗品，最后重结晶而得。

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