13750-81-7 1-甲基-1H-咪唑-2-甲醛

危险性质：非危险化学品

化学合成中间体。

化学合成

路线1：1-甲基咪唑为原料

• 步骤：向冷却至-70℃的1-甲基咪唑（8.2g，100mmol）的无水THF（100mL）溶液中滴加nBuLi的THF溶液，在相同温度下搅拌30分钟后，用新蒸馏的DMF（7.3g，100mmol）处理，将得到的黄色悬浮液在0℃下搅拌2小时，并用冰水淬灭，将混合物用EtOAc萃取，有机萃取物干燥（Na₂SO₄）后蒸发，得到油状残余物，减压蒸馏得到产物。
• 条件：Stage #1: With n-butyllithium In tetrahydrofuran at -70℃; for 0.50 h; Stage #2: at -70 - 0℃; for 2 h;
• 收率：68%
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