化学合成。
化学合成
合成路线 1（1. 合成：34595-26-1）
产率：92%
合成条件：With potassium carbonate In DMF (N,N-dimethyl-formamide) at 130℃; for 3 h;
实验步骤：向醛3a（20g，161.1mmol）的无水DMF（160ml）溶液中依次加入哌啶（19.1ml，193.4mmol，1.2当量）和碳酸钾（26.73g，193.4mmol，1.2当量）。 将悬浮液在130℃下加热3小时。 然后将反应混合物倒入冷水中。 用柠檬酸酸化至pH5。将水层用EtOAc萃取3次，并将合并的有机萃取物依次用水，饱和NaHCO3和盐水洗涤。 用MgSO 4干燥有机萃取物，过滤并浓缩，分离出所需的2-哌啶子基苯甲醛3b，为红色油状物（28.23g，收率92％）。
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