162012-67-1 N-(3-氯-4-氟苯基)-7-氟-6-硝基-4-喹唑啉胺

危险性质：非危险化学品

化学合成。

医药

合成路线 1（1. 合成：162012-67-1）

产率：100% 合成条件：for 4 h; Reflux 实验步骤：例1; （5 *，i ^ -N-（4-（3-氯-4-氟苯基氨基）-7-（四氢呋喃-3-基氧基）喹唑啉-6-基）-4-（D6-二甲基氨基）丁-2-烯酰胺 N-（3-氯-4-氟苯基）-7-氟-6-硝基喹唑啉-4-胺（2）; 230mg 1（1.0mmol）和146mg 3-氯-4-氟苯胺（1.0当量） 将该混合物悬浮于5ml异丙醇中并加热回流4小时，将混合物冷却至室温，真空蒸发溶剂，得到粗产物，将粗产物溶于二氯甲烷中，用10％NaOH溶液碱化。 分离并干燥，得到纯产物2，为黄色固体，收率100％.HPLC-MS：m / z：337 [M + 1] +。 参考文献：

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