3,5-二硝基溴苯是重要的有机合成中间体，可用于制备3-甲氧基-5-硝基溴苯等衍生物，进一步用于医药、农药等领域的化合物合成。
医药; 农药
路线1：
- 步骤: 将1,3-二硝基苯（25g，149mmol）溶解在硫酸（44.5mL，835mmol）中并加入NBS（31.8g，178mmol）。将混合物在60℃下搅拌2天。将反应冷却至环境温度，将混合物倒入冰水中形成沉淀。过滤收集产物，用水和己烷洗涤，得到35.1g（142mmol，96％）1-溴-3,5-二硝基苯，为米色固体。
- 条件: 60℃，搅拌48小时；
- 收率: 96%；
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路线2：
- 步骤: 将30.0 g 1,3-二硝基苯（0.18 mol）溶于180 mL浓硫酸中，加热至80°C，维持反应温度在80-90°C之间。将44.5 g N-溴代琥珀酰亚胺（NBS，0.25 mol）分9批次加入上述溶液，反应持续30分钟。反应完成后，冷却至室温，将反应混合物倒入600 mL冰水中，析出白色沉淀。经过滤、洗涤、干燥，得到白色固体3,5-二硝基溴苯41.3 g，收率93.7%。
