389574-20-3 马来酸普拉格雷

• 生物活性 Prasugrel (PCR 4099) Maleic acid，一种噻吩吡啶和前药，抑制血小板功能。Prasugrel Maleic acid 是一种有效的 P2Y12 受体拮抗剂，抑制 ADP 诱导的血小板聚集。
• 靶点 P2Y12 receptor
• 体外研究 In rat platelets, Prasugrel (PCR 4099) Maleic acid active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC 50 value of 1.8 μM. Prasugrel (PCR 4099) Maleic acid acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel hydrochloride is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel (PCR 4099) Maleic acid is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h.

医药