19914-36-4 (R)-2-乙酰氨基丙酸甲酯

危险性质：非危险化学品

化学合成；生命科学。

化学合成; 生命科学

合成路线 1（1. 合成：19914-36-4）

产率：99% 合成条件：With ((R,R)-1,2-bis(tert-butylmethylphosphino)-4,5-(methylenedioxy)benzene)(1,5-cyclooctadiene)rhodium (1+) hexafluoroantimonate; hydrogen In methanol at 20℃; for 0.33 h; 实验步骤：通用方法：作为反应底物，438.5mg（2.00mmol）α-脱氢氨基酸2-（N-乙酰氨基）-3-苯基-2-丙酸 - 甲酸酯，和作为不对称氢化催化剂，1.55mg加入（2.RxR）-1,2-双（叔丁基甲基膦基）-4,5-（亚甲二氧基）苯）（1,5-环辛二烯）铑（1 +）六氟锑酸盐，氢气进行五次吹扫，并加入预先脱气的5mE脱水甲醇。随后，将氢气压力设定为3个大气压，然后开始反应。在室温下搅拌30分钟后，停止容器中的氢消耗，因此假定反应终止。在将反应液浓缩后，将剩余的白色晶体溶解在乙酸乙酯中，然后通过硅胶柱。当用HPLC分析所得洗脱液时，得到（R）-2-（N-乙酰氨基）-3-苯基丙酸甲酯，对映体过量（cc）为99.9％。另外，使用1 H NMR分析化合物，化学收率为99％或更高（表1中的No.1）。在这种情况下，HPLC条件如下：HPLC：Daicel Chiralcel OJ，1.0mE / mm，己烷：2-丙醇9：1j0085]每种对映体的保留时间（R）t = 13.3mm，（S）t2 = 19.3mmj0086]此外，不对称氢化反应在上述相同条件下进行，除了如表1所示改变反应基质和反应条件的类型，结果也示于表1中。 参考文献：

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