49761-82-2 1-BOC-咪唑

危险性质：否

化学合成；生命科学。

化学合成;生命科学

路线1：以盐酸胍为催化剂的咪唑Boc保护反应

• 产率：100%
• 合成条件：以盐酸胍（15mol％）为催化剂，二碳酸二叔丁酯（1.2mmol）与咪唑（1mmol）在乙醇（1mL）中于35-40℃反应0.02h
• 实验步骤：将咪唑加入磁力搅拌的盐酸胍和二碳酸二叔丁酯的乙醇溶液中，在35-40℃搅拌至反应完成（TLC或GC监测）；真空蒸发乙醇，残余物用水洗涤或溶于二氯甲烷/乙酸乙酯后过滤分离催化剂；蒸发有机溶剂得几乎纯的产物；若使用过量二碳酸二叔丁酯，用石油醚或己烷洗涤产物回收残余物；必要时通过结晶（己烷/二氯甲烷或乙醚/石油醚）或硅胶柱色谱（乙酸乙酯-己烷=1:6洗脱）进一步纯化
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