34035-03-5 5-(4-氯苯基)-2-呋喃甲醛

干冰运输。危险性质：非危险化学品。WGK Germany:3。危险等级:IRRITANT。海关编码:29321900。存储类别:11 - 可燃固体。危险性类别:眼部刺激 类别2；经皮刺激 类别2；特异性靶器官毒性-一次接触，类别3。

作为呋喃甲醛衍生物，用于医药和农药相关研究与应用，具体用途需参考相关文献。

医药; 农药

路线1：

• 步骤: 根据报道方法合成并表征化合物5-芳基呋喃-2-甲醛（1-9），具体步骤参考[3,13]等文献。
• 条件: With hydrogenchloride; copper dichloride In water at -5℃
• 收率: 62%
• 参考文献: [1] Heterocyclic Communications, 2003, vol. 9, # 6, p. 625 - 628；[2] Synthetic Communications, 2005, vol. 35, # 3, p. 333 - 340；[3] Asian Journal of Chemistry, 2013, vol. 25, # 14, p. 7738 - 7742；[4] Asian Journal of Chemistry, 2017, vol. 29, # 4, p. 735 - 741；[5] Russian Journal of Organic Chemistry, 2009, vol. 45, # 9, p. 1375 - 1381；[6] Journal of Medicinal Chemistry, 2009, vol. 52, # 8, p. 2465 - 2481；[7] Patent: CN108203450, 2018, A.；[8] Patent: CN104449670, 2016, B.；[9] Kogyo Kagaku Zasshi, 1950, vol. 53, p. 81；[10] Chem.Abstr., 1953, p. 2164；[11] Mem. Fac. Eng. Kyoto, 1952, vol. 14, p. 195,204；[12] Rocziniki Chem., 1953, vol. 27, p. 54,60；[13] Chem.Abstr., 1954, p. 13678；[14] Kogyo Kagaku Zasshi, 1950, vol. 53, p. 81；[15] Chem.Abstr., 1953, p. 2164；[16] Mem. Fac. Eng. Kyoto, 1952, vol. 14, p. 195,204；[17] Rocziniki Chem., 1953, vol. 27, p. 54,60；[18] Chem.Abstr., 1954, p. 13678；[19] Arzneimittel-Forschung/Drug Research, 1983, vol. 33, # 10, p. 1411 - 1416；[20] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 19, p. 5370 - 5373；[21] European Journal of Medicinal Chemistry, 2010, vol. 45, # 12, p. 5576 - 5584；[22] Journal of Agricultural and Food Chemistry, 2010, vol. 58, # 5, p. 3037 - 3042；[23] Asian Journal of Chemistry, 2013, vol. 25, # 17, p. 9595 - 9600；[24] Patent: CN105777758, 2016, A.；[25] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 5, p. 545 - 549；[26] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 5, p. 545 - 549,5

路线2：

• 步骤: 将1.00mmol芳基卤化物，1.30mmol糠醛-硼酸和0.05mmol双（三苯基膦）二氯化钯（II）用0.30mL二甲氧基乙烷，0.50mL乙醇和0.30mL 2M碳酸钠水溶液处理，加热至65℃反应1小时或直到TLC显示无剩余起始材料，蒸发后乙酸乙酯萃取三次，合并有机层盐水洗涤，MgSO₄干燥，过滤浓缩，柱色谱纯化。
• 条件: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; ethanol; water at 65℃; for 1 h
• 收率: 95%
• 参考文献: [1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 929 - 936；[2] Chemical Biology and Drug Design, 2017, vol. 89, # 4, p. 585 - 598

路线3：

• 步骤: 向1-溴-4-氯苯（478mg，2.50mmol）在DME（7.5mL）和EtOH（5.0mL）的混合物中加入PdCl₂(PPh₃)₂（36.5mg，52.0μmol），5-甲酰基-2-呋喃硼酸（365mg，2.61mmol）和2M Na₂CO₃水溶液，60℃搅拌2小时，冷却至室温，减压除挥发性物质，加水后EtOAc萃取，有机层盐水洗涤，MgSO₄干燥，减压浓缩，硅胶柱色谱纯化。
• 条件: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; ethanol; water at 60℃; for 2 h
• 收率: 63%
• 参考文献: [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 21, p. 6384 - 6393,10；[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 36, p. 7402 - 7417