化学合成。
医药; 农药; 合成香料
合成路线 1（1. 合成：2859-78-1）
产率：91%
合成条件：With dihydrogen peroxide; ammonium bromide; acetic acid In water at 20℃; for 20 h;
实验步骤：实施例1：由藜芦醚制备4-溴-1,2-二甲氧基苯（1）向3.0L反应器中加入藜芦醚（142g，1.03mol）和溴化铵（110g，1.12mol，1.10当量）的乙酸溶液（1.6）L）。 将过氧化氢水溶液（30％）（180mL，1.76mol，1.67当量）滴加到反应混合物中，并将内容物在室温下搅拌。 20小时后，将反应混合物用饱和碳酸氢钠溶液处理，并用二氯甲烷（3×200mL）萃取。 将合并的有机萃取液用水（2×200mL）和盐水（200mL）洗涤，用无水硫酸钠干燥，然后减压蒸发，得到黄色液体。 蒸馏后，得到纯产物（202.7g，沸点128-133℃/ 10毫巴，91％）。 3 / 4NMR（400MHz，DMSO-13C NMR（100MHz，DMSO-“3/4）：δ150.3,148.8,123.5,115.3,113.8,112.3,56.2,56.0。
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