异喹啉-N-氧化物主要用于医药和农药领域,具体用途未在输入数据中详细说明。
医药; 农药
合成路线 1(1. 合成:1532-72-5)
产率:96%
合成条件:With dihydrogen peroxide In water for 0.25 h; Sonication
实验步骤:在50mL圆底烧瓶中,依次加入喹啉1.29g,过氧化氢(35%质量分数)1.1g,5质量%。全氟磺酸树脂,10ml水作为溶剂,所得混合物反应 在30 W / 20 KHz超声波反应器中进行15分钟。 过滤除去反应体系中的树脂催化剂,减压除去反应溶剂中的水,最后重结晶,得到相应的喹啉氮氧化物1.39g,收率96%。
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合成路线 2(2. 合成:1532-72-5)
产率:63%
合成条件:With urea hydrogen peroxide adduct In methanol at 0 - 20℃; for 7 h;
实验步骤:通用方法B在0℃下加入搅拌的胺(0.3-0.8mmol)的甲醇(0.5M)溶液,UHP(3mol当量)和催化剂1(2mol%)。 将混合物在室温下搅拌所需的时间(参见表2)。 反应混合物呈红橙色,根据胺类型在不同时间消失。 然后,反应混合物保持黄色,在某些情况下形成白色沉淀。 在减压下除去溶剂后,加入二氯甲烷,将形成的浆液通过硅藻土过滤。 蒸发溶剂并通过快速柱色谱法纯化粗残余物。
参考文献:
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