3-(4-甲基哌嗪-1-基)苯胺为胺类衍生物，用于有机及医药合成中。
有机合成; 医药合成
合成路线 1（1. 合成：148546-99-0）
产率：93%
合成条件：With hydrogen In ethanol for 2 h;
实验步骤：合成39; 向38（8.6g，39mmol）的乙醇（97mL）溶液中加入10wt％Pd / C（5.5g，1.6mmol）并将反应混合物氢化（50psi）2小时。 将反应混合物通过硅藻土过滤，并将滤饼用乙醇（300mL）洗涤。 减压浓缩滤液，得到39（6.9g，93％）：ESI MS m / z 192 [C 11 H 17 N 3 + H] +。EPO
参考文献：
- [1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5221 - 5224 [2] Patent: WO2007/18941, 2007, A2. Location in patent: Page/Page column 96-97 [3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119 [4] RSC Advances, 2018, vol. 8, # 22, p. 11871 - 11885 [5] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 39; 40 [6] Patent: WO2004/31164, 2004, A1. Location in patent: Page/Page column 43 [7] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 127 [8] Journal of Medicinal Chemistry, 2001, vol. 44, # 23, p. 3946 - 3955 [9] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269 [10] Patent: WO2006/17443, 2006, A2. Location in patent: Page/Page column 158 [11] Patent: WO2008/94737, 2008, A2. Location in patent: Page/Page column 32-33 [12] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6737 - 6746 [13] Patent: US2005/124637, 2005, A1. Location in patent: Page/Page column 12 [14] Patent: US2007/60577, 2007, A1. Location in patent: Page/Page column 48
