84955-31-7 2-氨基-4-氯吡咯并[2,3-D]嘧啶

危险性质：非危险化学品

化学合成。

医药

合成路线 1（1. 合成：84955-31-7）

产率：78% 合成条件：for 2 h; Reflux 实验步骤：将G005（10. 0g，66.6mmol）加入到100mLPOCl 3中，回流2小时，溶剂旋转。冷却至室温后，将反应混合物加入120mL冰水中，过滤固体，洗涤滤液。 用氨水溶液调至pH = 2，冰浴和沉淀物As过滤2h后，过滤固体，先用冰水10mL洗涤，30mL第二次冰用乙醚洗涤，8,7g后沥干，产率78％。。 参考文献：

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