948571-47-9 2-(4-氨基-1H-吡唑-1-基)乙醇

运输信息：冰袋运输。危险描述：非危险化学品。

化学合成

化学合成

合成路线：向50mL圆底烧瓶中加入1-(2-羟基乙基)-4-硝基-1H-吡唑（100mg，0.64mmol，1.00当量）、甲醇（5mL）和钯碳（20mg）；将反应混合物在氢气气氛下于室温搅拌1小时；反应完成后，通过过滤除去固体催化剂；将滤液在减压下浓缩，得到70mg（产率87%）的2-(4-氨基-1H-吡唑-1-基)乙醇（化合物22.2），为灰白色油状物。 参考文献：[1] Patent: WO2016/42341, 2016, A1. Location in patent: Page/Page column 184；[2] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00338; 00339；[3] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0342; 0344；[4] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 00081；[5] Patent: WO2007/99326, 2007, A1. Location in patent: Page/Page column 113；[6] Patent: WO2012/110986, 2012, A1. Location in patent: Page/Page column 56；[7] Patent: WO2013/17479, 2013, A1. Location in patent: Page/Page column 48；[8] Patent: WO2015/48281, 2015, A1. Location in patent: Paragraph 00413; 00415；[9] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0303-0304