6089-04-9 2-(2-丙炔-1-氧基)四氢-2H-吡喃

危险性质：非危险化学品

化学合成。

化学合成

合成路线 1（1. 合成：6089-04-9）

产率：97.2% 合成条件：With toluene-4-sulfonic acid In dichloromethane at 0 - 20℃; for 1 h; 实验步骤：O-THP炔丙醇（18）化合物18根据文献程序制备.24至炔丙醇17（2.6mL，44.6mmol）和p-TsOH一水合物（0.09g，0.5mmol）在CH 2 Cl 2（45mL）中的溶液在0℃下滴加DHP（4.3mL，46.8mmol）。在0℃下搅拌5分钟后，将反应混合物温热至室温并搅拌1小时。接下来，将反应混合物用饱和NaHCO 3（30mL）洗涤，并将水层用CH 2 Cl 2（45mL）萃取。合并的有机层经MgSO 4干燥，过滤，并在减压下浓缩，得到化合物18（6.1g，97.2％），为黄色油状物。 Rf = 0.30（正己烷/ Et2O 95/5）。 1H NMR（400MHz，CDCl3）：δ= 1.50-1.67（m，4H），1.70-1.89（m，2H），2.41（t，J = 2.4Hz，1H），3.52-3.57（m，1H），3.82 -3.87（m，1H），4.27（ddd，J = 2.4Hz，11.3Hz，15.8Hz，2H），4.83（t，J = 3.4Hz，1H）。 13 C NMR（100MHz，CDCl 3）：δ= 19.0,25.3,30.2,53.9,61.9,74.0,79.7,96.8。 MS-CI：m / z计算值C 8 H 12 O 2 [M + H] +，141;实测值：141。发现，141。此化合物也曾在此前报道过 参考文献：

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