19249-03-7 三甘醇二对甲苯磺酸酯

危险性质：否

三甘醇二对甲苯磺酸酯作为有机合成中间体，在医药研发及相关有机化学反应中发挥作用，用于构建特定分子结构。

医药; 有机合成

合成路线 1（1. 合成：19249-03-7）

产率：99% 合成条件：With potassium hydroxide In dichloromethane at 0 - 10℃; for 3 h; 实验步骤：通用方法：化合物2a-c通过文献1中已知的改进方法制备。 将低聚乙二醇（37.7mmol）和对甲苯磺酰氯（14.4g，75.4mmol，2当量）溶解在二氯甲烷（36mL）中，将该溶液冷却至0℃。 在永久搅拌期间，加入研磨的氢氧化钾（17g，302mmol，8当量），然后将溶液搅拌3小时，同时将温度保持在0至10℃。 通过TLC（UV检测）监测该反应。 升温至室温后，将反应混合物用氯仿稀释，用水（3×1：1）萃取。 收集氯仿萃取物，用硫酸镁干燥过夜，过滤并减压蒸发溶剂。 参考文献：

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