化学合成。
化学合成
合成路线 1（1. 合成：6484-25-9）
产率：87%
合成条件：for 2 h; Reflux
实验步骤：在0℃下向磁力搅拌的POCl 3（25mL）溶液中分批加入2-苯基喹唑啉-4（3H） - 酮10（5.0g）。 将反应混合物回流2小时。 反应完成后，真空除去过量的POCl 3。 将残余物倒入氯仿（50mL）+冰冷水（80mL）+氨溶液（20mL）的混合物中。 分离氯仿层，水层用另外的20mL氯仿萃取。 将合并的氯仿萃取液用Na 2 SO 4干燥并过滤，蒸馏除去溶剂，得到11,4.5g（87％）; 熔点125-127℃（lit.24 124-125℃）; 1H NMR（DMSO-d6）δ7.58-7.69（4H，m，4.x ArH），7.91-7.92（2H，m，2.x ArH），8.16-8.21（3H，m，3.x。ARH）。。 （C 14 H 9 ClN 2）：C，H，N。
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