1127-45-3 8-羟基喹啉-N-氧化物

运输信息：冰袋运输。危险描述：危险品运输编号UN 3077 9/PG 3，WGK Germany:3，RTECS号VC8238500，F:3-10，海关编码29334900，存储类别11 - 可燃固体。非危险化学品。

化学合成；卤化喹啉类抗阿米巴药物的中间体

医药

合成路线 1（1. 合成：1127-45-3）

• 产率：97%
• 合成条件：With manganese dioxide; dihydrogen peroxide In dichloromethane
• 实验步骤：（1）将59.74g（411mmol）的8-羟基喹啉、350ml（822mmol）的二氯甲烷、82.2ml的35％过氧化氢水溶液和0.52g（2.5mmol）的三甲基甲苯（MTO）置于1L圆底烧瓶中。将反应混合物在室温（25℃）下搅拌24小时，然后连续加入80ml过氧化氢水溶液和0.32g二氧化锰。将混合物搅拌1小时30分钟，然后通过沉降分离各相。用二氯甲烷（2×200ml）萃取水相。合并有机相，用硫酸钠干燥，过滤并真空浓缩，得到64g橙色固体形式的8-羟基喹啉N-氧化物；m.p. = 112℃（产率：97％）
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