化学合成。
化工医药中间体; 实验室研发; 化工医药合成
合成路线 1（1. 合成：5315-25-3）
产率：93.1%
合成条件：Stage #1: at 60 - 62℃; for 1 h; Stage #2: at -5 - -3℃; for 3 h; Stage #3: With sodium nitrite In water for 3 h;
实验步骤：在搅拌条件下，反应罐中质量浓度为46％氢溴酸盐756g，2-氨基-6-甲基吡啶108g，加热至60-62℃保温1h，然后冷却至-5 - -3°C，保持 温度范围为640g溴Br2，再保温3h; 在温度范围内滴加质量浓度为30％的亚硝酸钠水溶液920g，完成滴加，不受反应温度控制，搅拌反应3h; 反应结束时，反应液温度降至15°C后，用于质量浓度为30％的氢氧化钠水溶液调节pH = 11，然后通过水蒸气蒸馏得到2-溴-6-甲基吡啶150g， 蒸气含量为99.4％，收率为93.1％;
参考文献：
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