化学合成；食品添加剂。
化学合成；食品添加剂；农药（抑制杂草）
合成路线 1（1. 合成：1080-12-2）
产率：88%
合成条件：With sodium hydroxide In ethanol; water at 0 - 20℃;
实验步骤：通用方法：在0-5℃下，向取代的苯甲醛（6a1-d1,6e，6f）和丙酮（10-25当量，过量）的乙醇溶液中加入20％（w / v）NaOH水溶液。 将反应混合物在环境温度下搅拌，并通过TLC监测反应进程。 当取代的苯甲醛被消耗时，在真空中除去过量的丙酮; 然后加入冷水，用3M HCl酸化所得溶液。 通过真空过滤收集作为固体出现的产物，用水洗涤并真空干燥。 通过柱色谱法纯化残余物或者从适当的溶剂系统中重结晶，得到取代的4-苯基丁-3-烯-2-酮7a1-d1,7e和7f。
参考文献：
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合成路线 2（2. 合成：1080-12-2）
产率：98%
合成条件：at 90℃; for 0.50 h; Green chemistry
实验步骤：通用方法：将适当的芳香醛（1eq。）和叶立德I或II（1.3-1.5eq。）在水（4-10mL）中的悬浮液在90℃下搅拌0.5-24h。 接下来，将非均相反应混合物冷却至室温，并用DCM（3×10mL）萃取水相。在减压下蒸发溶剂。 残余物经柱色谱（己烷 - 乙酸乙酯，或氯仿 - 甲醇）得到E-烯烃作为主要产物。
参考文献：
- [1] Molecules, 2018, vol. 23, # 9, [2] Phosphorus, Sulfur and Silicon and Related Elements, 1998, vol. 143, p. 33 - 44 [3] Liebigs Annalen der Chemie, 1983, # 12, p. 2135 - 2140
