化学合成，医药来那度胺中间体。
医药
合成路线 1（1. 合成：59382-59-1）
产率：98%
合成条件：for 2 h; Reflux
实验步骤：将式II化合物（40.0g，0.22mol）悬浮在甲醇（500ml）中，加入亚硫酰氯（32.6ml，0.44mol）溶液，将混合物加热回流2小时。 将所得反应物倒入水（500ml）中搅拌，沉淀出白色固体状物。 过滤，滤饼用水洗涤并减压干燥，得到2-甲基-3-硝基苯甲酸甲酯（III）（42g），产率（98％）
参考文献：
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