化学合成。
医药; 化工
合成路线 1（1. 合成：2913-97-5）
产率：99%
合成条件：for 1 h; Heating / reflux
实验步骤：实施例5：N-2- [4-（4-溴-2-氟 - 苯基氨基）-7-（1-甲基 - 哌啶-4-基甲氧基） - 喹唑啉-6-基氨基] - 乙基 - 丙烯酰胺的制备<5 -1,1-（1,3-二氧代-1,3-二氢 - 异吲哚-2-基） - 乙醛; 将邻苯二甲酰亚氨基乙醛二乙基缩醛（10g，0.0379mol）溶解在100ml 1N HCl水溶液中，回流所得溶液并搅拌1小时。 当反应终止时，将反应溶液用200ml二氯甲烷萃取，用100ml盐溶液洗涤，并在减压下蒸馏，得到标题化合物7.16g（产率：99％）。1H NMR（CDCl3）δ ：9.66（s，1H），7.90-7.84（m，2H），7.78-7.73（m，2H），4.56（s，2H）。
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