2913-97-5 N-(2-乙醛基)邻苯二甲酰亚胺

危险性质：非危险化学品

化学合成。

医药; 化工

合成路线 1（1. 合成：2913-97-5）

产率：99% 合成条件：for 1 h; Heating / reflux 实验步骤：实施例5：N-2- [4-（4-溴-2-氟 - 苯基氨基）-7-（1-甲基 - 哌啶-4-基甲氧基） - 喹唑啉-6-基氨基] - 乙基 - 丙烯酰胺的制备<5 -1,1-（1,3-二氧代-1,3-二氢 - 异吲哚-2-基） - 乙醛; 将邻苯二甲酰亚氨基乙醛二乙基缩醛（10g，0.0379mol）溶解在100ml 1N HCl水溶液中，回流所得溶液并搅拌1小时。 当反应终止时，将反应溶液用200ml二氯甲烷萃取，用100ml盐溶液洗涤，并在减压下蒸馏，得到标题化合物7.16g（产率：99％）。1H NMR（CDCl3）δ ：9.66（s，1H），7.90-7.84（m，2H），7.78-7.73（m，2H），4.56（s，2H）。 参考文献：

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合成路线 2（2. 合成：2913-97-5）

产率：95% 合成条件：With hydrogenchloride; water In acetonitrile at 20℃; for 24 h; 实验步骤：（1,3-二氧代-1,3-二氢 - 异吲哚-2-基） - 乙醛4的合成：向含有10mL CH 3 CN的圆底烧瓶中的化合物3（0.470g，2mmol）的搅拌溶液中加入 加入10毫升10％HCl溶液。 将反应混合物在室温下搅拌24小时。 减压蒸发有机溶剂，用乙酸乙酯萃取含水残余物，用无水Na 2 SO 4干燥，浓缩，得到白色固体。 得到产物4，收率95％（0.359g），熔点87-88℃。 1 H NMR（300MHz，CDCl 3）：δ4.58（s，2H），7.72-7.80（m，2H），7.84-7.91（m，2H），9.66（s，1H）。 参考文献：

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