15771-06-9 5-(苄氧基)-2-(羟甲基)-4H-吡喃-4-酮

危险性质：非危险化学品

化学合成。

化学合成

合成路线 1（1. 合成：15771-06-9）

产率：83% 合成条件：With sodium hydroxide In methanol; water for 18.50 h; Reflux 实验步骤：将曲酸（11）（14.20g，100mmol）溶解在甲醇（100mL）中，并加入氢氧化钠（4.40g，110mmol）的水（10mL）溶液。 将反应混合物加热至回流。 然后在30分钟内滴加苄基氯（13.92g，110mmol）并回流18小时。 浓缩反应混合物，向残余物中加入二氯甲烷（400mL）。 滤除无机盐。 用5％氢氧化钠溶液（100mL），水（100mL）洗涤二氯甲烷，用Na 2 SO 4干燥，过滤，浓缩并从乙醇中重结晶，得到浅黄色固体（12b）（19.26g，83％）。 参考文献：

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