医药; 农药; 化学试剂; 精细化学品; 药物研发
合成路线 1（1. 合成：4926-28-7）
产率：86%
合成条件：Stage #1: With hydrogen bromide; bromine In water at -20 - -15℃; for 3 h; Stage #2: With sodium nitrite In water at 20℃; for 3 h; Stage #3: With sodium hydroxide In water at 0℃;
实验步骤：在-20℃下向2-氨基-4-甲基吡啶（120g，1.1mol）在48％HBr（1.5L）中的溶液中逐滴加入溴（160mL，3.11mol）。 将反应混合物在-15℃至-20℃搅拌3小时。向上述混合物中分批加入NaNO 2水溶液（204g，2.95mol）。 然后将反应混合物在3小时内温热至室温。 加入20％NaOH水溶液（在2L水中1.2Kg NaOH）溶液，将pH调节至12，保持温度在0℃。用乙醚（3.x.250mL）萃取反应混合物，洗涤 用水，盐水洗干。 除去溶剂并通过分馏纯化，得到2-溴-4-甲基吡啶（164g，86％），为浅黄色液体。
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