3-溴苯并噻吩可用于化学合成和材料科学领域，尤其在有机发光二极管（OLED）中作为空穴传输层材料，能提高器件性能和寿命。此外，它还可用于合成医药产品、精细化学品及构建功能性材料。
化学合成；材料科学；有机发光二极管
路线1：
- 步骤：将卤代杂环（0.66mmol）在无水THF（13.2mL）中脱气，依次加入PdCl₂(dppf)（27.0mg，0.033mmol，5.0mol%）、TMEDA（0.130g，1.12mmol，1.7当量）和NaBH₄（42.4mg，1.12mmol，1.7当量），室温氩气下搅拌适当时间后后处理。
- 条件：With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 25℃; Inert atmosphere
- 收率：85%
- 参考文献：[1] Journal of Organic Chemistry, 2012, vol. 77, #21, p.9921-9925；[2] Journal of Molecular Catalysis A: Chemical, 2014, vol. 393, p.191-209；[3] Patent: WO2015/188790, 2015, A1
路线2：
- 步骤：在0℃下，向苯并[b]噻吩（10g，74.5±16mmol）的氯仿（75mL）和乙酸（75mL）溶液中逐步加入NBS（16.6g，93.268mmol）4小时，室温搅拌48小时后，用氯仿稀释，依次用饱和硫代硫酸钠、碳酸钠、盐水洗涤，干燥、蒸发后硅胶柱层析分离。
- 条件：With N-Bromosuccinimide; acetic acid In chloroform at 0 - 20℃; for 52 h
- 收率：100%
- 参考文献：[1] Tetrahedron, 2004, vol. 60, #14, p.3221-3230；[2] Patent: WO2014/186035, 2014, A1；[3] Journal of the American Chemical Society, 2018, vol. 140, #20, p.6432-6440；[4] Tetrahedron Letters, 2004, vol. 45, #42, p.7943-7946；[5] Chemistry of Materials, 2010, vol. 22, #17, p.5031-5041；[6] Patent: KR2015/27443, 2015, A；[7] Patent: US6828332, 2004, B1；[8] Journal of Organic Chemistry, 2015, vol. 80, #15, p.7530-7535；[9] Patent: CN108250058, 2018, A；[10] Patent: US2008/21026, 2008, A1；[11] Chemical Communications, 2017, vol. 53, #36, p.5044-5047；[12] Journal of Organic Chemistry, 2014, vol. 79, #3, p.1138-1144；[13] Chemistry Letters, 2018, vol. 47, #8, p.1044-1047；[14] Tetrahedron Letters, 2018, vol. 59, #28, p.2717-2721；[15] Chemical Communications, 2008, #46, p.6227-6229；[16] Synlett, 2004, #3, p.461-464；[17] Tetrahedron, 1989, vol. 45, #24, p.7869-7878；[18] Chemical Communications, 2009, #42, p.6460-6462；[19] Patent: KR2016/2328, 2016, A；[20] Tetrahedron, 1994, vol. 50, #41, p.11893-11902；[21] Patent: US5371093, 1994, A；[22] European Journal of Organic Chemistry, 2006, #9, p.2100-2109；[23] Zeitschrift fuer Physikalische Chemie (Muenchen, Germany), 1981, vol. 127, p.13-22；[24] Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1980, vol. 19, #12, p.1183-1187；[25] Journal fuer Praktische Chemie (Leipzig), 1929, vol. <2> 122, p.329；[26] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946, vol. 222, p.1441；[27] Journal of the American Chemical Society, 1950, vol. 72, p.571,575；[28] Synlett, 2002, #12, p.2083-2085；[29] Journal of Medicinal Chemistry, 2000, vol. 43, #7, p.1293-1310；[30] Patent: US4659717, 1987, A；[31] Patent: US4548948, 1985, A；[32] Angewandte Chemie - International Edition, 2012, vol. 51, #8, p.1934-1937；[33] Russian Chemical Bulletin, 2012, vol. 61, #7, p.1456-1462；[34] Izv. Akad. Nauk, Ser. Khim., 2012, #7, p.1441-1447,7；[35] Patent: WO2015/188790, 2015, A1；[36] Angewandte Chemie - International Edition, 2016, vol. 55, #27, p.7737-7741；[37] Angew. Chem., 2016, vol. 128, p.7868-7872,5；[38] Chem, 2017, vol. 3, #3, p.428-436
