6552-63-2 1-(4-氯苯基)-3-(4-甲氧基苯基)-2-丙烯-1-酮

1-(4-氯苯基)-3-(4-甲氧基苯基)-2-丙烯-1-酮主要用于医药和农药领域，具体用途未在提供的信息中详细说明，但根据其化学结构和相关研究，可能作为有机合成中间体或具有生物活性的化合物用于药物研发和农业化学品制备。

医药; 农药

合成路线 1（1. 合成：6552-63-2）

产率：96.9% 合成条件：With methanol; sodium In methanol at 20℃; 实验步骤：一般步骤：将Na（0.01g，0.4mmol）切成片，并在冰浴下加入无水MeOH（15mL）中; 制备新鲜的MeONa / MeOH溶液直至不产生气体。 将4-甲氧基苯甲醛（1.36g，10.0mmol）加入到新鲜的冷却的MeONa / MeOH溶液（15mL）中，然后滴加10.0mmol乙酰基芳族化合物。 将混合物在室温下搅拌2-8小时（36-54小时，2和2和/或萘基的对其他物质的阻隔）。 通过TLC监测反应的结果。 然后，将水（20mL）和EtOAc（75mL，25mL×3）加入混合物中。 除去无机沉淀，将有机溶液用盐水洗涤三次并干燥。 将粗产物通过硅胶柱色谱法纯化，用EtOAc /己烷作为洗脱剂，得到纯的α，β-不饱和羰基化合物（2a-2o）。 参考文献：

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合成路线 2（2. 合成：6552-63-2）

产率：83% 合成条件：at 25 - 30℃; for 2.17 h; 实验步骤：通用方法：将α，β-不饱和酰氯（501mg，3mmol），芳香族化合物（324mg，3mmol）和氧化锌（120mg，1.5mmol）的混合物在室温下搅拌（25-30℃） °C）指定时间（表2）。 通过TLC监测反应进程。 反应完成后，用二氯甲烷（3×5mL）萃取产物，用水洗涤萃取液。碳酸氢钠。 将有机层用无水Na 2 SO 4干燥，并在减压下除去溶剂，得到分析纯的产物，产率为92％（219mg）。 参考文献：

• [1] Catalysis Communications, 2012, vol. 27, p. 30 - 32