体外研究
Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM.
Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation.
Chelidonic acid is a glutamate decarboxylase inhibitor, with a K
i
of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.
体内研究
Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.
