化学合成；制药。
化学合成; 制药
合成路线 1（1. 合成：5416-80-8）
产率：95%
合成条件：Stage #1: at 1 - 5℃; for 0.33 h; Stage #2: at 35℃; for 0.67 h; Stage #3: at 95℃; for 0.50 h; Cooling with ice
实验步骤：通用程序：将POCl 3（1.73mL，18.6mmol）缓慢滴加到搅拌和冰冷却的DMF（5.0mL）中。 将反应混合物在1-5℃下搅拌20分钟，然后缓慢加入相应的取代的2-甲基吲哚6（15.5mmol）的DMF（5.0mL）溶液。 将所得反应混合物缓慢升温至35℃并在该温度下保持40分钟。 然后将其冷却至室温。 向该混合物中加入冰（~10g），然后加入5M NaOH溶液（31mL，155mmol）。 将反应混合物在95℃加热30分钟，然后使其冷却至室温。 向该混合物中再次加入冰（~10g），并将所得反应混合物搅拌30分钟。 过滤收集所需产物并用水洗涤数次。
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