15291-76-6 银杏内酯C

WGK Germany:3 F:10-21 海关编码:29322090

• 生物活性 Ginkgolide C 是从银杏叶中分离到的黄酮类物质，具有多种生物功能，可以减少血小板聚集，改善阿尔兹海默症等。
• 靶点 AMPK MMP-9 Human Endogenous Metabolite Sirtuin
• 体外研究 Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets.
• 化学性质 白色结晶体，易溶于甲醇，来源于银杏叶。
• 银杏内酯C对治疗心、脑血管疾病有很好的辅助作用。
• 用于含量测定/鉴定/药理实验等。 药理药效:银杏内酯C对治疗心、脑血管疾病有很好的辅助作用。

医药