化学合成。
医药
合成路线 1（1. 合成：23680-40-2）
产率：98%
合成条件：With N-Bromosuccinimide; silver nitrate In acetone at 20 - 32℃;
实验步骤：向溶解在丙酮（2L）中的丙炔酸甲酯（60g，713.6mmol）中加入N-溴代琥珀酰亚胺（147.22g，827.13mmol），然后加入硝酸银（12.12g，71.37mmol）。 观察到轻微的放热，反应温度从21-32℃升高，然后将反应混合物在室温下搅拌过夜。 将得到的灰色悬浮液真空蒸发至干，加入戊烷（100mL）并通过Celite过滤，用更多的戊烷洗涤。 该过程再进行两次，然后将合并的滤液真空蒸发，得到113g 3-溴丙醇甲酯（98％收率），含有约10％的原料.1 H NMR（400MHz，CDCl 3）δppm3.78（s， 3 H）。
参考文献：
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