73963-72-1 西洛他唑

危险性质：非危险化学品

化学合成；生命科学；医药，抗血小板药。

医药

合成路线 1（1. 合成：73963-72-1）

产率：92.5% 合成条件：With potassium carbonate; sodium hydroxide; sodium sulfite In ethanol for 8 h; Reflux 实验步骤：在5000L反应器中，加入1-环己基-5-（4-氯丁基）-1,2,3,4-四唑296g（1.22mol），6-羟基-3,4-二氢喹诺酮180g（1.1mol） ，碳酸钾385克（2.79摩尔），氢氧化钠36克（0.9摩尔），亚硫酸钠9克（0.071摩尔），66.7％乙醇1600克，保持回流8小时，反应完成后，加入600克 水，搅拌，回流40min，分层，将碱性水相转移至废水系统，将有机相还原至5度，搅拌结晶，过滤，用部分乙醇冲洗。 将其在85℃下减压干燥，得到377g白色固体，产率92.5％，纯度99.8％。 熔点159。 参考文献：

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