100643-71-8 地氯雷他定

运输信息：冰袋运输。危险描述：非危险化学品，WGK Germany:3，RTECS号:DE8011000，海关编码:2933399090，存储类别:11 - 可燃固体，危险品运输编码:1993。

作为选择性H1受体拮抗剂，具有抗过敏和抗炎活性，用于治疗季节性过敏性鼻炎、慢性特发性荨麻疹等过敏性疾病；是氯雷他定的活性代谢物，可通过选择性拮抗外周H1受体缓解相关症状，体外研究显示能抑制组胺从人肥大细胞释放，动物研究提示不易通过血脑屏障。

医药

路线1：

• 步骤：将40g氯雷他定、40g氢氧化钠、500ml无水乙醇和125ml纯净水加入反应烧瓶中，在氮气氛下回流反应，浓缩至大量固体沉淀，过滤、洗涤并干燥，得到地氯雷他定32g。
• 条件：Reflux; Inert atmosphere; Alkaline conditions；氯雷他定与氢氧化钠的摩尔比为1:20；纯净水与无水乙醇的体积比为1:4。
• 收率：98.5%。
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