93703-24-3 8-溴-3-甲基-3,7-二氢-嘌呤-2,6-二酮

运输方式为冰袋运输。危险性质：非危险化学品。海关编码:29339900。

化学合成，医药利拉利汀中间体；利拉利汀中间体；利拉利汀的中间体。

医药

合成路线 1（1. 合成：93703-24-3）

• 步骤: 向3-甲基-1H-嘌呤-2,6(3H,7H)-二酮的溶液（11.3g，6.8mmol）中加入乙酸钠（8.37g，13.6mmol），然后在50℃下滴加溴（13.04g，8.2mmol）。添加后，将混合物在65℃下搅拌3小时。冷却混合物并倒入冰水（500g）中，产物沉淀。过滤浆液，滤饼用水洗涤两次，真空干燥，得到8-溴-3-甲基-1H-嘌呤-2,6(3H,7H)-二酮（16.1g，96.6％收率）为浅黄色固体。
• 条件: With bromine; sodium acetate In acetic acid at 50 - 65℃; for 3 h;
• 收率: 96.6%
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