化学合成。
化学合成
合成路线 1（1. 合成：754230-78-9）
产率：81%
合成条件：With sulfuric acid; bromine; acetic acid In water at 0 - 4℃; for 4.50 h;
实验步骤：将2-氨基-3-苄氧基吡啶（85.0g，0.42mol）溶于10％硫酸水溶液（1000ml）中。将黄色溶液冷却至0至4℃并在2小时内滴加溴（80.5g，0.50mol）的乙酸（276g，4.6mol）溶液。得到红色悬浮液，将其在0℃下搅拌2.5小时，然后倒入冰水（500ml）和二氯甲烷（1000ml）的混合物中。通过向充分搅拌的两相混合物中加入25％氨水溶液（约600ml）来调节pH值为8。分离各相，水相用二氯甲烷（3×500ml）萃取。将合并的有机相用水（400ml）洗涤并用硫酸钠干燥。减压除去溶剂，残余物通过快速色谱法纯化[1kg硅胶，洗脱剂：石油醚/乙酸乙酯= 7：3（v / v）]。因此，分离出96.0g标题化合物，为棕色固体（81％收率）。熔点：109-110℃1H-NMR（CDCl3,200MHz）：8 = 4.73（bs，2H），5.04（s，2H），7.08（d，1H），7.40（me，5） H），7.73（d，1H）。
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