21900-52-7 5-溴-2-氯苯甲酰氯

危险品运输编号:UN1759 危险等级:8

5-溴-2-氯苯甲酰氯是重要的有机合成中间体，广泛应用于医药和农药领域的相关化合物合成。

医药; 农药

合成路线 1（1. 合成：21900-52-7）

产率：100% 合成条件：With oxalyl dichloride In DMF (N,N-dimethyl-formamide); dichloromethane at 20 - 25℃; 实验步骤：将8.00kg 2-氯-5-溴苯甲酸悬浮于80.00L二氯甲烷（二氯甲烷KF <0.1％H2O）中，并在20℃下加入0.02L DMF。缓慢加入5.18Kg草酰氯并保持内部温度低于 25℃。添加略微放热; 发生了HCl和CO2的气体逸出。 反应在20-25℃下进行过夜; 获得了明确的解决方案。 将混合物真空浓缩成油状残余物，并在40℃下真空脱气。 2-氯-5-溴苯甲酰氯的产量：8.63kg（33.98mol，产率100.0％） 参考文献：

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