38870-89-2 甲氧基乙酰氯

危险品运输编号UN 2920 8/PG 2，WGK Germany:3，F:9-19-21，危险等级8，包装类别II，海关编码29189900，存储类别3-易燃液体。危险性类别：急性毒性（吸入，类别3）、严重眼损伤（类别1）、易燃液体（类别3）、皮肤腐蚀（类别1B）。

甲氧基乙酰氯是杀菌剂恶霜灵、甲霜灵的中间体，用作医药、染料中间体。

医药; 农药; 染料

路线1：草酰氯酰氯化法

• 步骤: 在0℃下，向化合物54a（20mL，0.26mol）的DCM（170mL）溶液中逐滴加入草酰氯（30mL，0.34mol）和几滴DMF。将混合物在室温下搅拌过夜并蒸发。蒸馏残余物，得到54b（25.4g，90％）。
• 条件: With oxalyl dichloride In dichloromethane at 0 - 20℃
• 收率: 90%
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• 步骤: 在反应瓶中投入甲醇和片状NaOH，回流反应30min；冷却后加入一定量的氯乙酸，升温反应2h；回流结束后蒸去甲醇，共沸脱水至水脱尽；冷却到10℃以下，加入甲苯和SOCl₂为酰化剂，在45℃左右反应1h；冷却到20℃，经后处理，蒸馏得到产品。
• 反应式: CH₃ONa + ClCH₂COOH → CH₃OCH₂COONa；CH₃OCH₂COONa + SOCl₂ → CH₃OCH₂COCl + NaCl + SO₂↑
• 条件: 甲醇与NaOH回流反应30min；氯乙酸反应升温2h；SOCl₂酰化反应45℃左右1h
• 收率: 未明确提及（原始数据中未提供具体收率）