225240-71-1 4-甲基-4-哌啶甲酸乙酯盐酸盐

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名称和标识

中文名: 4-甲基-4-哌啶甲酸乙酯盐酸盐
英文名: Ethyl 4-methylpiperidine-4-carboxylate hydrochloride
CAS号: 225240-71-1
分子式: C9H18ClNO2
分子量: 207.7
中文别名: 4-甲基哌啶-4-甲酸乙酯盐酸盐; 4-甲基哌啶-4-羧酸乙酯盐酸盐
英文别名: Ethyl 4-methylpiperidine-4-carboxylate HCl; ethyl 4-methylpiperidine-4-carboxylate,hydrochloride; ethyl 4-methylpiperidine-4-carboxylate monohydrochloride; 4-Piperidinecarboxylic acid, 4-methyl-, ethyl ester, hydrochloride (1:1); Ethyl 4-methyl-4-piperidinecarboxylate hydrochloride (1:1)

安全说明

运输信息：常温运输。危险描述：非危险化学品。

用途与制备

化学合成

步骤: 将4M氯化氢的1,4-二恶烷（3mL）溶液加入到4-乙基4-甲基哌啶-1,4-二甲酸叔丁酯（0.34g，1.25mmol）的乙醇溶液（4mL）中，搅拌6小时；反应完成后，蒸发溶剂，残余物用乙醚处理，过滤并用乙醚洗涤，得到标题化合物的盐酸盐（0.3g，99％）。
条件: 20℃；1,4-二恶烷、乙醇为溶剂；反应时间6小时。
收率: 99%
参考文献: [1] Patent: WO2015/86693, 2015, A1. Location in patent: Page/Page column 121 [2] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 114 [3] Patent: WO2015/86525, 2015, A1. Location in patent: Page/Page column 117; 118 [4] Patent: WO2006/83003, 2006, A1. Location in patent: Page/Page column 37 [5] Patent: WO2006/59945, 2006, A1. Location in patent: Page/Page column 69 [6] Patent: US2012/88750, 2012, A1. Location in patent: Page/Page column 17; 18 [7] Patent: US2013/252938, 2013, A1. Location in patent: Paragraph 0466 [8] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 24, p. 6598 - 6603

步骤: 将4M氯化氢的1,4-二恶烷溶液（3mL）缓慢加入到N-Boc-4-甲基-4-哌啶甲酸乙酯（0.34g，1.25mmol）的乙醇溶液（4mL）中，搅拌6小时；反应完成后，通过旋转蒸发仪除去溶剂，残余物用乙醚处理，过滤并用乙醚洗涤，得到4-甲基-4-哌啶甲酸乙酯盐酸盐（0.3g，收率99%）。
条件: 室温；1,4-二恶烷、乙醇为溶剂；反应时间6小时。
收率: 99%
参考文献: [1] Patent: WO2015/86693, 2015, A1. Location in patent: Page/Page column 121 [2] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 114 [3] Patent: WO2015/86525, 2015, A1. Location in patent: Page/Page column 117; 118 [4] Patent: WO2006/83003, 2006, A1. Location in patent: Page/Page column 37 [5] Patent: WO2006/59945, 2006, A1. Location in patent: Page/Page column 69