化学合成。
医药
合成路线 1（1. 合成：10601-19-1）
产率：94%
合成条件：Stage #1: at 0℃; for 1 h; Stage #2: at 20℃; for 5 h; Stage #3: With sodium hydroxide In N,N-dimethyl-formamide at 100℃; for 0.17 h;
实验步骤：一般程序：在搅拌下以逐滴方式将草酰氯（0.3mL）加入冷却的（冰浴）DMF（3mL）中。 然后将混合物在0℃下搅拌1小时。 然后将取代的吲哚（4mmol）的DMF（1.5mL）溶液以逐滴的方式加入到反应混合物中。 将得到的混合物在室温下搅拌5小时。 然后加入2N氢氧化钠溶液（2mL），并将混合物在100℃加热10分钟。 然后将混合物冷却并用乙酸乙酯（3×50mL）萃取。 合并有机层，依次用水和盐水洗涤。 将有机物干燥（Na 2 SO 4）并蒸馏至干，得到粗残余物，将其通过快速柱色谱法纯化，使用乙酸乙酯/石油醚（3：1，v / v）作为洗脱剂，得到纯的吲哚-3-甲醛。（图4a-K）。
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