化学合成；生命科学。
化学合成；生命科学；医药中间体；生化研究
合成路线 1（1. 合成：2133-40-6）
产率：100%
合成条件：for 2 h; Inert atmosphere; Reflux
实验步骤：由（S） - 脯氨酸（10.2g，88.6mmol）和SOCl 2（11.6g，7.10mL，97.5mmol）在回流的MeOH（60mL）中制备（S） - 吡咯烷-2-羧酸甲酯29小时。 随后除去过量溶剂和SOCl 2，得到脯氨酸酯（15.9g，定量），为灰色油状物.30根据文献15，由2-氟-1-硝基苯（6.92g，5.18mL）制备标题化合物1。 ，49.0mmol）和（S） - 吡咯烷-2-羧酸甲酯（7.55g，45.6mmol），为亮黄色晶体（12.0g，定量），无需进一步纯化即可使用。
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