19309-14-9 小豆蔻明

危险性质：非危险化学品

• 理化性质 小豆蔻明(Cardamonin)，为黄色针晶，易溶于甲醇、乙醇、醋酸乙酯，乙醚，稀碱溶液，难溶于水，与醋酸铅反应呈黄色沉淀。小豆蔻明可以明显抑制络氨酸酶的活性，同时可以有效抑制黑色素细胞增殖和黑色素的合成，效果明显超过其他成分。
• 生物活性 (E)-Cardamonin ((E)-Cardamomin) 是新颖的hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
• 靶点 Target Value NF-κB (Cell-free assay) TRPA1 (Cell-free assay) 454 nM
• 体外研究 (E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC 50 =454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
• 体内研究 (E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
• 化学性质 黄色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于草豆蔻。
• 小豆蔻明具有抗菌、止呕、健脾的作用。
• 用于含量测定/鉴定/药理实验等

医药

来源于草豆蔻。